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Portrait of Steven Niederer

Steven Niederer

Group lead · Imperial College London, Stanford University

Professor Steven Niederer received a Bachelor of Engineering majoring in Engineering science at the University of Auckland, New Zealand, before completing a DPhil in Computer Science at the University of Oxford, United Kingdom. He received a UK Engineering and Physical Sciences Research Council (EPSRC) post-doctoral fellowship on modelling heart failure before being appointed as a lecturer at King’s College London. Since joining King’s College Steven has developed a research group focused on developing and applying computational simulation and image analysis techniques to better understand cardiac physiology, pathologies and treatments. His work is characterised by working across disciplines spanning statistics, computer science, engineering, physiology and cardiology.

Research themes

In the news

  1. FIMH 2027 is coming to London
  2. Steven Niederer joins Stanford as Professor of Medicine
  3. Fetal heart digital twins at the World Congress in Fetal Medicine
  4. One model to segment the heart across CT and MRI
  5. OpenEP|NET, a national platform for heart rhythm data, is funded
  6. A workshop on the mathematics of cancer digital twins
  7. Fickle Heart 2025 in Sheffield
  8. The group receives Imperial's President's Award for Excellence in Impact
  9. MIT Technology Review on digital twins of the heart
  10. Steven Niederer gives a Barbara Ell lecture in Sydney
  11. Interview: building digital twins of the heart
  12. The group joined the National Heart and Lung Institute at Imperial
  13. The first systematic review of cardiac in silico trials
  14. A workshop on cardiac digital twins in London

Papers

First author 30

  1. Steven A Niederer, Maximilian Balmus, Christopher Burr, Timothy J A Chico, Richard H Clayton, Wenjia Bai, …, Sheng-Ya Wang, …

    Digital twins for cardiopulmonary medicine: the case for pulmonary arterial hypertension

    American Journal of Respiratory and Critical Care Medicine, 2026

  2. Steven Niederer, Henry Chubb, Kenneth C. Bilchick, Christopher Aldo Rinaldi

    Leadless and extravascular cardiac resynchronization therapy: the future for CRT?

    Nature Reviews Cardiology, 2025

  3. Steven Niederer, Bradley Porter, C. Aldo Rinaldi

    To the Editor — Multisite pacing strategies: Solutions looking for a problem?

    Heart Rhythm O2, 2020

  4. S. A. Niederer, Y. Aboelkassem, C. D. Cantwell, C. Corrado, S. Coveney, E. M. Cherry, …, M. Riabiz, C. H. Roney, …

    Creation and application of virtual patient cohorts of heart models

    Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, 2020

  5. Steven A. Niederer, Kenneth S. Campbell, Stuart G. Campbell

    A short history of the development of mathematical models of cardiac mechanics

    Journal of Molecular and Cellular Cardiology, 2018

  6. Steven Niederer, Anna Sher

    Quantitative Systems Pharmacology: Modelling and simulating drug action in health and disease

    Progress in Biophysics and Molecular Biology, 2018

  7. Steven A. Niederer, Joost Lumens, Natalia A. Trayanova

    Computational models in cardiology

    Nature Reviews Cardiology, 2018

  8. Steven A. Niederer, Christopher A. Rinaldi

    Is CRT response rate all about patient selection?

    International Journal of Cardiology, 2018

  9. S A Niederer, J Gould, B Sieniewicz, F Prinzen, C A Rinaldi

    Is the rapidly paced pig the optimal model for endocardial cardiac resynchronization therapy?

    EP Europace, 2017

  10. Steven A. Niederer, Bernardo L. de Oliveira, Michael J. Curtis

    The opportunities and challenges for biophysical modelling of beneficial and adverse drug actions on the heart

    Current Opinion in Systems Biology, 2017

  11. Steven A. Niederer, Nic P. Smith

    Using physiologically based models for clinical translation: predictive modelling, data interpretation or something in‐between?

    The Journal of Physiology, 2016

  12. Steven Niederer, Cameron Walker, Andrew Crozier, Eoin R. Hyde, Bojan Blazevic, …

    The impact of beat-to-beat variability in optimising the acute hemodynamic response in cardiac resynchronisation therapy

    Clinical Trials and Regulatory Science in Cardiology, 2015

The 12 most recent of 30. All of them are under Every group paper.

Middle author 337

  1. Neil Bodagh, Vinush Vigneswaran, Ali Gharaviri, Irum Kotadia, Magda Klis, …, Steven Niederer, …

    Atrial fibrillation phenotypes derived from multimodal data exhibit distinct electrophysiological substrate characteristics, symptom trajectories, and ablation outcomes

    European Heart Journal Open, 2026

  2. P.J. Luthert, L. Faes, A.J. Foss, D.J. Fu, L.J. Hill, …, S. Niederer, …

    The Virtual Eye: An integrative multiscale framework for mechanistic modelling of ocular physiology and disease

    Progress in Retinal and Eye Research, 2026

  3. Nikki van Pouderoijen, Luuk H.G.A. Hopman, Melati Post, Joris R. de Groot, Cassia Kessler-Iglesias, …, Steven A. Niederer, …

    Right Atrial Cardiomyopathy Assessed by Late Gadolinium Enhancement Cardiac MRI Following Pulmonary Vein Isolation in Patients with Atrial Fibrillation

    Heart Rhythm, 2026

  4. Olivier Bernard, William A. Romero R., Cyprien Bouton, Celia Goujat, Hang Jung Ling, …, Abdul Qayyum, …, Steven A. Niederer, …

    The MYOSAIQ Challenge: Myocardial Segmentation with Automated Infarct Quantification

    The Journal of Machine Learning for Biomedical Imaging, 2026

  5. Radka Jersakova, Sam F. Greenbury, Ed Chalstrey, Edwin Brown, Marjan Famili, …, Max Balmus, …, Steve Niederer, …

    AutoEmulate: A PyTorch tool for end-to-end emulation workflows

    The Journal of Open Source Software, 2026

  6. Vishal Mehta, Nadeev Wijesuriya, Felicity De Vere, Sandra Howell, Mark K Elliott, …, Steven A Niederer, …

    Redefining response to cardiac resynchronization therapy: a post hoc analysis of the MORE-CRT MPP trial

    EP Europace, 2026

  7. Christopher Burr, Steven Niederer, David Wagg

    Digital Well-Being in an Age of AI-Enabled Digital Twins

    Routledge eBooks, 2026

  8. Kaiyuan Yang, Fabio Musio, Yihui Ma, Norman Juchler, Johannes C. Paetzold, …, Abdul Qayyum, …, Steven Niederer, …

    The TopCoW Challenge — Topology-Aware Circle of Willis Segmentation for CT and MR Angiography

    NEJM AI, 2026

  9. Muhammad Imran, Jonathan R. Krebs, Vishal Balaji Sivaraman, Teng Zhang, Amarjeet Kumar, …, Abdul Qayyum, …, Steven A. Niederer, …

    Multi-class segmentation of aortic branches and zones in computed tomography angiography: The AortaSeg24 challenge

    Medical Image Analysis, 2026

  10. Xichong Liu, Abdul Qayyum, Sabyasachi Bandyopadhyay, Sulaiman Somani, Prasanth Ganesan, Rayan A. Ansari, …, Steven Niederer, …

    Identifying the Presence and Characteristics of Mid-Myocardial and Epicardial Fibrosis From Intracardiac Electrograms in Patients Undergoing Ventricular Arrhythmia Ablation Using a Transformer-Based Self-Supervised Classifier

    Circulation Arrhythmia and Electrophysiology, 2026

  11. Fay Frost, Maximilian Balmus, Levan Bokeria, Joe Longbottom, Camila Rangel-Smith, Harry Saxton, …, Steve Niederer, …

    Rapid personalisation of cardiovascular models using invasively measured right ventricular pressure

    Computers in Biology and Medicine, 2026

  12. Mahmoud Ehnesh, Haseeb Valli, Ovais A. Jaffery, Sam Coveney, Alexander Zolotarev, …, Steven A. Niederer, …, Caroline Roney

    Comparative multimodal calibration of patient‐specific atrial fibrillation models: Impact of imaging and electrophysiology data on arrhythmogenic substrate identification

    The Journal of Physiology, 2026

The 12 most recent of 337. All of them are under Every group paper.

Last author 164

  1. Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer

    In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

    Clinical Pharmacology & Therapeutics, 2026

  2. Shuang Qian, Devran Ugurlu, Elliot Fairweather, Richard E. Jones, Hassan Zaidi, Sanjay Prasad, Brian P. Halliday, …, Cristobal Rodero, Abdul Qayyum, …, Martin Bishop, Steven Niederer

    In silico trials for sex-specific patient inclusion criteria in cardiac resynchronization therapy

    npj Digital Medicine, 2026

  3. Cristobal Rodero, Lara Curran, Christopher W. Lanyon, Paolo Inglese, Abdul Qayyum, Rosie K. Barrows, Jose A. Solis-Lemus, Shahrokh Rahmani, Marina Strocchi, Angela W.C. Lee, Tiffany M.G. Baptiste, Ludovica Cicci, Edward Burford, Elias Karabelas, …, Steven A. Niederer

    Computational models show that functional remodeling, not anatomy, reshapes physiological determinants of cardiac performance in hypertrophic cardiomyopathy

    Journal of Molecular and Cellular Cardiology, 2026

  4. Shambhavi Malik, Ludovica Cicci, Abdul Qayyum, Rahul Ghelani, Ji-jian Chow, Jagdeep Singh Mohal, Zachary I. Whinnett, …, Steven A. Niederer

    Body surface potential driven personalisation of electrophysiological digital twins in hypertrophic cardiomyopathy

    PLoS Computational Biology, 2026

  5. Aditi Kulkarni, Rosie K. Barrows, Angela W.C. Lee, Caroline H. Roney, Marina Strocchi, Edward J. Vigmond, Gernot Plank, Nicholas Panay, Steven A. Niederer

    Multiscale modelling of hormonal effects on atrial fibrillation in female physiology

    The Journal of Precision Medicine Health and Disease, 2026

  6. José Alonso Solís-Lemus, Rosie K. Barrows, Cristobal Rodero, Marina Strocchi, Natalie Montarello, Nishant Lahoti, Cesare Corrado, Abdul Qayyum, Shahrokh Rahmani, Caroline Roney, Gernot Plank, Christoph Augustin, …, Steven A. Niederer

    Assessing the importance of sex and disease-specific anatomy in electrophysiology and mechanical simulations with a newly developed public virtual cohort of four-chamber heart models

    PLoS Computational Biology, 2026

  7. C Corrado, C H Roney, S M Narayan, W R Giles, S A Niederer

    The effects of alterations of plasma electrolytes on post-repolarisation refractoriness

    EP Europace, 2026

  8. Angela W.C. Lee, Marina Strocchi, Alphonsus Liew, Sandra Howell, Felicity De Vere, Nadeev Wijesuriya, …, Steven Niederer

    Computational analysis of intracardiac collision risk and optimal site for right ventricular leadless left bundle branch area pacing: A simulation study

    Heart Rhythm O2, 2026

  9. Abdul Qayyum, Moona Mazher, M. K. A. Ahamed Khan, Ridzuan A., Mastaneh Mokayef, …, Steven Niederer

    Deep Spatiotemporal Convolutional Network for Brain Reperfusion Prediction using Multiphase Computed Tomographic Angiography and Clinical Data

    WSEAS Transactions on Signal Processing archive, 2026

  10. Christopher David Burr, Shuang Qian, Peter Winter, Tim Chico, Camila Rangel Smith, David Wagg, Steven Alexander Niederer

    Realising the digital twin: a thematic review and analysis of the ethical, legal, and social issues for digital twins in healthcare

    AI & Society, 2026

  11. Alexandre Lewalle, Gregory Milburn, Jania Bell, Kenneth S. Campbell, Steven A. Niederer

    Human atrial skinned muscle fibers exhibit reduced length-dependent activation but show faster force development kinetics than ventricular muscle

    Journal of Molecular and Cellular Cardiology, 2026

  12. Adelisa Avezzú, Stefano Longobardi, Anita Alvarez-Laviada, Francisca Schultz, Julia Gorelik, Catherine Williamson, Steven A. Niederer

    A model for the human fetal ventricular myocyte electrophysiology

    PLoS Computational Biology, 2026

The 12 most recent of 164. All of them are under Every group paper.