Angela Lee

Postdoctoral researcher · Imperial College London

Dr Angela WC Lee received her PhD in Biomedical Engineering from the University of Auckland, New Zealand. Her main research interest is in modelling cardiac resynchronization therapy using patient-specific models of the heart. Previously, her work focused on modelling the chronic changes in the heart’s electrophysiology, mechanics and geometry due to cardiac resynchronisation therapy and the effect that these changes will have on the optimal lead location. The current focus of her work is on developing a product for image-guided optimisation of wireless endocardial pacemakers for patients undergoing cardiac resynchronization therapy. This project, in collaboration with medical imaging companies, device manufacturers, and clinicians, aims to translate image-analysis and advanced simulations tools into the clinic to assist in pre-procedural planning for wireless endocardial CRT.

Research themes

In the news

6 June 20263D-printed hearts at the Great Exhibition Road Festival

Papers

First author 10

Angela W.C. Lee, Marina Strocchi, Alphonsus Liew, Sandra Howell, Felicity De Vere, Nadeev Wijesuriya, …, Steven Niederer
Computational analysis of intracardiac collision risk and optimal site for right ventricular leadless left bundle branch area pacing: A simulation study
Heart Rhythm O2, 2026
Angela W C Lee, Charles Sillett, José Alonso Solis-Lemus, Cassia Kessler Iglesias, Luuk H G A Hopman, Alina Hua, Peter Wheen, Abdul Qayyum, Marina Strocchi, Caroline Roney, …, Steven A Niederer
Is regional atrial strain a useful surrogate of regional atrial fibrosis in atrial cardiomyopathy?
European Heart Journal - Imaging Methods and Practice, 2025
Angela W. C. Lee, Marina Strocchi, Cristobal Rodero, Caroline Mendonca Costa, Steven A. Niederer
Computational Biomechanics of Ventricular Dyssynchrony and Resynchronization Therapy
Cardiac and vascular biology, 2023
Angela W.C. Lee, Orod Razeghi, Jose Alonso Solis-Lemus, Marina Strocchi, Baldeep Sidhu, Justin Gould, Jonathan M. Behar, Mark Elliott, …, Steven A. Niederer
Non-invasive simulated electrical and measured mechanical indices predict response to cardiac resynchronization therapy
Computers in Biology and Medicine, 2021
Angela W.C. Lee, Declan P. O'Regan, Justin Gould, Baldeep Sidhu, Benjamin Sieniewicz, …, Steven A. Niederer
Sex-Dependent QRS Guidelines for Cardiac Resynchronization Therapy Using Computer Model Predictions
Biophysical Journal, 2019
A.W.C. Lee, U.C. Nguyen, O. Razeghi, J. Gould, B.S. Sidhu, B. Sieniewicz, …, S. Niederer
A rule-based method for predicting the electrical activation of the heart with cardiac resynchronization therapy from non-invasive clinical data
Medical Image Analysis, 2019
Angela Lee, Uyen Chau Nguyen, Justin Gould, Baldeep Sidhu, Benjamin Sieniewicz, Caroline Mendonca Costa, …, Steven Niederer
Predicting Activation Patterns in Cardiac Resynchronization Therapy Patients
Computing in cardiology, 2018
Angela W C Lee, Caroline Mendonca Costa, Marina Strocchi, Christopher A Rinaldi, Steven A Niederer
Computational Modeling for Cardiac Resynchronization Therapy
Journal of Cardiovascular Translational Research, 2018
ANGELA W. C. LEE, ANDREW CROZIER, EOIN R. HYDE, PABLO LAMATA, MICHAEL TRUONG, …, STEVEN NIEDERER
Biophysical Modeling to Determine the Optimization of Left Ventricular Pacing Site and AV/VV Delays in the Acute and Chronic Phase of Cardiac Resynchronization Therapy
Journal of Cardiovascular Electrophysiology, 2016
Angela Lee, Manav Sohal, Jonathan Behar, Simon Claridge, Anoop Shetty, …, Steven Niederer
Personalised Biophysical Model to Optimise Left Ventricle Pacing Location for Cardiac Resynchronisation Therapy Over Time
Computing in cardiology, 2016

Middle author 30

Cristobal Rodero, Lara Curran, Christopher W. Lanyon, Paolo Inglese, Abdul Qayyum, Rosie K. Barrows, Jose A. Solis-Lemus, Shahrokh Rahmani, Marina Strocchi, Angela W.C. Lee, Tiffany M.G. Baptiste, Ludovica Cicci, Edward Burford, Elias Karabelas, …, Steven A. Niederer
Computational models show that functional remodeling, not anatomy, reshapes physiological determinants of cardiac performance in hypertrophic cardiomyopathy
Journal of Molecular and Cellular Cardiology, 2026
Aditi Kulkarni, Rosie K. Barrows, Angela W.C. Lee, Caroline H. Roney, Marina Strocchi, Edward J. Vigmond, Gernot Plank, Nicholas Panay, Steven A. Niederer
Multiscale modelling of hormonal effects on atrial fibrillation in female physiology
The Journal of Precision Medicine Health and Disease, 2026
Luca Soattin, Leila Topal, Roman Tikhomirov, Daniele Lagomarsino-Oneto, Sami Al-Othman, Angela W C Lee, …, Steven A Niederer, …
Endurance exercise remodels pulmonary vein sleeve myocytes and promotes a proarrhythmic atrial substrate
European Heart Journal, 2026
Tiffany M.G. Baptiste, Cristobal Rodero, Charles P. Sillett, Marina Strocchi, Christopher W. Lanyon, Christoph M. Augustin, Angela W. C. Lee, José Alonso Solís-Lemus, Caroline H. Roney, Daniel B. Ennis, Ronak Rajani, …, Steven A. Niederer
Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models
PLoS Computational Biology, 2025
S Samaneh Lashkarinia, Angela W C Lee, Tiffany M G Baptiste, Rosie K Barrows, Charles P Sillett, Cristobal Rodero, Upasana Tayal, Antonio de Marvao, Nicholas Panay, Catherine Williamson, …, Marina Strocchi, Steven A Niederer
Representation of women in cardiovascular disease management: a systematic analysis of ESC guidelines
Open Heart, 2025
Charles Sillett, Vitaliy Androshchuk, Edouard Long, Tiffany M.G. Baptiste, Marina Strocchi, Jose Alonso Solis Lemus, Angela WC. Lee, Caroline H. Roney, Ronak Rajani, Tiffany Patterson, …, Steven A. Niederer
Three-dimensional left atrial strain from retrospective gated computed tomography: Comparison with speckle-tracking echocardiography in patients with aortic stenosis
Journal of cardiovascular computed tomography, 2025
C Kessler Iglesias, J. Pouliopoulos, R. Johnson, N. Olsen, A. Lee, S. Niederer, C. Hayward, …
Atrial Structure and Function in Subjects With DCM-Associated Truncating Titin Gene Variants
Heart Lung and Circulation, 2025
Alexandre Lewalle, Tiffany M. G. Baptiste, Rosie K. Barrows, Ludovica Cicci, Cesare Corrado, Angela W. C. Lee, Cristobal Rodero, José Alonso Solís-Lemus, Marina Strocchi, Steven A. Niederer
Developing cardiac biomechanical models beyond the clinic: modeling stressors of daily life
Biomechanics and Modeling in Mechanobiology, 2025
Charles Sillett, Orod Razeghi, Tiffany M G Baptiste, Angela W C Lee, Jose Alonso Solis Lemus, Cristobal Rodero, Caroline H Roney, Ruibin Feng, Prasanth Ganesan, Hui Ju Chang, Paul Clopton, …, Steven A Niederer
Identification of atrial myopathy and atrial fibrillation recurrence after ablation using 3D left atrial phasic strain from retrospective gated computed tomography
European Heart Journal - Imaging Methods and Practice, 2025
Shahrokh Rahmani, Jim Pouliopoulos, Angela Lee, Rosie Kate Barrows, Marina Strocchi, Cristobal Rodero, Abdul Qayyum, Caroline H. Roney, Christoph Augustin, Gernot Plank, Andrew Jabbour, …, Steven Niederer
Cardiac Sensitivities to Biomechanical Changes in a Chronic Alcoholic Heart: A Case Study Using 3-Dimensional Electro-Mechanical Heart Modelling
Computing in cardiology, 2024
Abdul Qayyum, Moona Mazher, Angela Lee, Jose A. Solis-Lemus, Imran Razzak, Steven A. Niederer
Assessment of Left Atrium Motion Deformation Through Full Cardiac Cycle
Lecture notes in computer science, 2024
Johanna Tonko, Angela Lee, N. Mannakkara, Steven E. Williams, Reza Razavi, Martin Bishop, Mark O'Neill, Steven Niederer, …
Structural phenotyping in atrial fibrillation with combined cardiac CT and atrial MRI: Identifying and differentiating individual structural remodelling types in AF
Journal of Cardiovascular Electrophysiology, 2024

The 12 most recent of 30. All of them are under Every group paper.