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Portrait of Alexandre Lewalle

Alexandre Lewalle

Postdoctoral researcher · Imperial College London

Dr Alex Lewalle completed his PhD in physics at Cambridge, and subsequently directed his research toward the physics/biology interface. His general research interest is in the mechanisms of force generation in biological systems, from the molecular to the whole-organ scale. His earlier research, combining experimental and modelling approaches, has included measurements of the myosin motor protein that produces muscle contraction, and of red-blood-cell membrane deformation. He has also modelled the dynamics of actin filament growth, the mechanical driving force in cell motility. Since joining CEMRG, his research has focused on understanding, through modelling and computational simulations, the roles played by electrophysiological activity, sarcomere-level molecular interactions, and cardiac tissue structure in producing heart muscle contraction. By comparing theoretical biophysical models with clinical data, he investigates the biophysical mechanisms of cardiac function in healthy hearts and in heart failure.

Research themes

Papers

First author 10

  1. Alexandre Lewalle, Gregory Milburn, Jania Bell, Kenneth S. Campbell, Steven A. Niederer

    Human atrial skinned muscle fibers exhibit reduced length-dependent activation but show faster force development kinetics than ventricular muscle

    Journal of Molecular and Cellular Cardiology, 2026

  2. Alexandre Lewalle, Tiffany M. G. Baptiste, Rosie K. Barrows, Ludovica Cicci, Cesare Corrado, Angela W. C. Lee, Cristobal Rodero, José Alonso Solís-Lemus, Marina Strocchi, Steven A. Niederer

    Developing cardiac biomechanical models beyond the clinic: modeling stressors of daily life

    Biomechanics and Modeling in Mechanobiology, 2025

  3. Alexandre Lewalle, Gregory Milburn, Kenneth S. Campbell, Steven A. Niederer

    Cardiac length-dependent activation driven by force-dependent thick-filament dynamics

    Biophysical Journal, 2024

  4. Alexandre Lewalle, Gregory Milburn, Kenneth S. Campbell, Steven A. Niederer

    Modeling mechanisms of the thick-filament off-state dynamics in cardiac muscle

    Biophysical Journal, 2023

  5. Alex Lewalle, Kenneth S. Campbell, Stuart G. Campbell, Gregory N. Milburn, Steven A. Niederer

    Functional and structural differences between skinned and intact muscle preparations

    The Journal of General Physiology, 2021

  6. Alexandre Lewalle, Sander Land, Jort J. Merken, Anne Raafs, Pilar Sepúlveda, …, Steven A. Niederer

    Balance of Active, Passive, and Anatomical Cardiac Properties in Doxorubicin-Induced Heart Failure

    Biophysical Journal, 2019

  7. Alexandre Lewalle, Sander Land, Eric Carruth, Lawrence R. Frank, Pablo Lamata, …, Steven A. Niederer, …

    Decreasing Compensatory Ability of Concentric Ventricular Hypertrophy in Aortic-Banded Rat Hearts

    Frontiers in Physiology, 2018

  8. Alexandre Lewalle, Sander Land, Steven Niederer

    Development of a Patient‐Based Computational Modeling Framework for Analyzing the Mechanisms of Doxorubicin Cardiotoxicity

    The FASEB Journal, 2017

  9. Alexandre Lewalle, Steven A. Niederer, Nicolas P. Smith

    Species‐dependent adaptation of the cardiac Na+/K+ pump kinetics to the intracellular Na+ concentration

    The Journal of Physiology, 2014

  10. Alexandre Lewalle, Steven Niederer, Nic Smith

    Species-Specific Comparison of the Cardiac Sodium/Potassium Pump Based on a Minimal Biophysical Model

    Biophysical Journal, 2014

Middle author 7

  1. Cristobal Rodero, Tiffany M. G. Baptiste, Rosie K. Barrows, Alexandre Lewalle, Steven A. Niederer, Marina Strocchi

    Advancing clinical translation of cardiac biomechanics models: a comprehensive review, applications and future pathways

    Frontiers in Physics, 2023

  2. Marcha Verheijen, Ugis Sarkans, Witold Wolski, Danyel Jennen, Florian Caiment, …, Alex Lewalle, …, Steven Niederer, …

    Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds

    Scientific Data, 2022

  3. Nathalie Selevsek, Florian Caiment, Ramona Nudischer, Hans Gmuender, Irina Agarkova, …, Alex Lewalle, …, Steven Niederer, …

    Network integration and modelling of dynamic drug responses at multi-omics levels

    Communications Biology, 2020

  4. S. Longobardi, A. Lewalle, S. Coveney, I. Sjaastad, E. K. S. Espe, W. E. Louch, …, S. A. Niederer

    Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats

    Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, 2020

  5. Kiarash Tazmini, Michael Frisk, Alexandre Lewalle, Martin Laasmaa, Stefano Morotti, David B. Lipsett, …, Steven A. Niederer, …

    Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes

    Circulation Research, 2020

  6. Stefano Longobardi, Alexandre Lewalle, Cynthia J. Musante, Anna Sher, Steven A. Niederer

    Quantifying Contributions of Cellular Mechanical Myocardial Properties on Left Ventricular Contractile Function in Aortic Banded Rats

    Biophysical Journal, 2020

  7. J. M. Aronsen, J. Skogestad, A. Lewalle, W. E. Louch, K. Hougen, M. K. Stokke, …, S. Niederer, …

    Hypokalaemia induces Ca 2+ overload and Ca 2+ waves in ventricular myocytes by reducing Na + ,K + ‐ATPase α 2 activity

    The Journal of Physiology, 2014