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Portrait of Stefano Longobardi

Stefano Longobardi

PhD student (previous member) · Imperial College London · joined 2018, until 2022

Stefano Longobardi graduated in Mathematics at Sapienza - University of Rome, Italy. He then obtained a Master’s Degree in Mathematics applied to Life Sciences from University of Trento, Italy, with final thesis project focused on a novel non-invasive technique to estimate the pressure jump inside blood vessels. From 2018 to 2022, Stefano did PhD in Biomedical Engineering at King’s College London, working on a multi-scale model of bi-ventricular rat hearts. He aims to identify drug molecular targets which are strongly linked to heart mechanics, in order to recover impaired left ventricle contractility function in pressure-overload-induced cardiac hypertrophic rat hearts. In order to do this, Stefano is employing computational models of cellular electrophysiology and calcium dynamics, sarcomere contraction and whole-organ mechanics, and lately some supervised learning techniques such as Gaussian processes and support vector machines. Along with his lifelong passion for mathematical formalism and abstract structures, Stefano has got a wide range of science-related interests including biology, quantum physics and astronomy. His next position was as quantitative systems toxicologist at GSK.

Papers

First author 5

  1. Stefano Longobardi, Anna Sher, Steven A. Niederer

    Quantitative mapping of force–pCa curves to whole‐heart contraction and relaxation

    The Journal of Physiology, 2022

  2. Stefano Longobardi, Anna Sher, Steven A. Niederer

    In silico identification of potential calcium dynamics and sarcomere targets for recovering left ventricular function in rat heart failure with preserved ejection fraction

    PLoS Computational Biology, 2021

  3. Stefano Longobardi, Anna Sher, Steven A. Niederer

    In Silico Mapping of the Omecamtiv Mecarbil Effects from the Sarcomere to the Whole-Heart and Back Again

    Lecture notes in computer science, 2021

  4. S. Longobardi, A. Lewalle, S. Coveney, I. Sjaastad, E. K. S. Espe, W. E. Louch, …, S. A. Niederer

    Predicting left ventricular contractile function via Gaussian process emulation in aortic-banded rats

    Philosophical Transactions of the Royal Society A Mathematical Physical and Engineering Sciences, 2020

  5. Stefano Longobardi, Alexandre Lewalle, Cynthia J. Musante, Anna Sher, Steven A. Niederer

    Quantifying Contributions of Cellular Mechanical Myocardial Properties on Left Ventricular Contractile Function in Aortic Banded Rats

    Biophysical Journal, 2020

Middle author 8

  1. Adelisa Avezzú, Stefano Longobardi, Anita Alvarez-Laviada, Francisca Schultz, Julia Gorelik, Catherine Williamson, Steven A. Niederer

    A model for the human fetal ventricular myocyte electrophysiology

    PLoS Computational Biology, 2026

  2. Marina Strocchi, Stefano Longobardi, Christoph M. Augustin, Matthias A. F. Gsell, Argyrios Petras, Christopher A. Rinaldi, …, Steven A. Niederer

    Cell to whole organ global sensitivity analysis on a four-chamber heart electromechanics model using Gaussian processes emulators

    PLoS Computational Biology, 2023

  3. Cristobal Rodero, Stefano Longobardi, Christoph Augustin, Marina Strocchi, Gernot Plank, Pablo Lamata, Steven A. Niederer

    Calibration of Cohorts of Virtual Patient Heart Models Using Bayesian History Matching

    Annals of Biomedical Engineering, 2022

  4. Damiano Fassina, Caroline M. Costa, Stefano Longobardi, Elias Karabelas, Gernot Plank, Sian E. Harding, Steven A. Niederer

    Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design

    PLoS Computational Biology, 2022

  5. Elias Karabelas, Stefano Longobardi, Jana Fuchsberger, Orod Razeghi, Cristobal Rodero, Marina Strocchi, Ronak Rajani, Gundolf Haase, Gernot Plank, Steven Niederer

    Global Sensitivity Analysis of Four Chamber Heart Hemodynamics Using Surrogate Models

    IEEE Transactions on Biomedical Engineering, 2022

  6. Cristobal Rodero, Marina Strocchi, Maciej Marciniak, Stefano Longobardi, John Whitaker, Mark D. O’Neill, Karli Gillette, …, Steven A. Niederer

    Linking statistical shape models and simulated function in the healthy adult human heart

    PLoS Computational Biology, 2021

  7. Orod Razeghi, Marina Strocchi, Angela Lee, Stefano Longobardi, Baldeep S. Sidhu, Justin Gould, Jonathan M. Behar, Ronak Rajani, …, Steven A. Niederer

    Tracking the motion of intracardiac structures aids the development of future leadless pacing systems

    Journal of Cardiovascular Electrophysiology, 2020

  8. Åsmund T Røe, Marianne Ruud, Emil K Espe, Ornella Manfra, Stefano Longobardi, Jan M Aronsen, …, Steven A Niederer, …

    Regional diastolic dysfunction in post-infarction heart failure: role of local mechanical load and SERCA expression

    Cardiovascular Research, 2018

Last author 1

  1. Damiano Fassina, Caroline Mendonca Costa, Sian Harding, steven niederer, Stefano Longobardi

    Modelling the Effects of Conductive Polymers and Stem Cells Derived Myocytes on Scarred Heart Tissue

    Computing in cardiology, 2020