A Quantitative Analysis of Cardiac Myocyte Relaxation: A Simulation Study, Steven Niederer, Peter Hunter, Nicholas Smith, 2006 Biophysical Journal, 90 1697-1722 PubMed ID: 16339881 A biophysical data driven model of length, velocity and calcium dependent tension development in rat cardiac muscle at room temperature.
Niederer and Smith Contraction Model 2006
Niederer and Smith Cell Model 2007
A Mathematical Model of the Slow Force Response to Stretch in Rat Ventricular Myocytes , Steven Niederer, Nicholas Smith, 2007 Biophysical Journal , Volume 92(11) pp.4030-4044, PubMed ID: 17369410 A coupled model of rat electrophysiology, calcium dynamics, pH regulation and contraction at room temperature
Li, Niederer et al., Mouse Cell Model 2010
A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform A Mathematical Model of the Slow Force Response to Stretch in Rat Ventricular Myocytes ,L. Li , S. A. Niederer , W. Idigo , Y. H. Zhang , P. Swietach , B. Casadei , N. P. Smith, 2010 American Journal of Physiology, Voume 299 no. H1045-H1063 A mouse electrophysiology model fitted to mouse data at physiological temperatures and capable of pacing to physiological pacing rates.
Land, Niederer et al., Mouse Contraction Model 2012
An analysis of deformation-dependent electromechanical coupling in the mouse heart. Land S, Niederer SA, Aronsen JM, Espe EK, Zhang L, Louch WE, Sjaastad I, Sejersted OM, Smith NP. J Physiol. 2012 15;590(Pt 18):4553-69. Epub 2012 May 21. PubMed ID: 22615436 A model of contraction fitted to mouse data at physiological temperature and frequency, including length and velocity dependent tension generation.
Land and Niederer, Detailed Contraction Model 2015
A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges. Land S, Niederer SA. PLoS Computational Biology, 2015 A spatially detailed ODE model of contraction based on continuous flexible chain model of the thin filament. Includes explicit TnI kinetics and a biophysically detailed representation of RU-RU, RU-XB, and XB-XB cooperativity.
Land, Niederer et al., Human Contraction Model 2017
A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes. S Land, SJ Park-Holohan, NP Smith, CG Dos Remedios, JC Kentish, SA Niederer. JMCC, 2017 A model of human cardiac contraction intended for multi-scale modelling applications. Download includes relevant experimental data, and C++ code is available on request.