Niederer and Smith Contraction Model 2006


A Quantitative Analysis of Cardiac Myocyte Relaxation: A Simulation Study, Steven Niederer, Peter Hunter, Nicholas Smith, 2006 Biophysical Journal, 90 1697-1722 PubMed ID: 16339881

A biophysical data driven model of length, velocity and calcium dependent tension development in rat cardiac muscle at room temperature.

Niederer and Smith Cell Model 2007


A Mathematical Model of the Slow Force Response to Stretch in Rat Ventricular Myocytes , Steven Niederer, Nicholas Smith, 2007 Biophysical Journal , Volume 92(11) pp.4030-4044, PubMed ID: 17369410

A coupled model of rat electrophysiology, calcium dynamics, pH regulation and contraction at room temperature

Li, Niederer et al., Mouse Cell Model 2010


A mathematical model of the murine ventricular myocyte: a data-driven biophysically based approach applied to mice overexpressing the canine NCX isoform A Mathematical Model of the Slow Force Response to Stretch in Rat Ventricular Myocytes ,L. Li , S. A. Niederer , W. Idigo , Y. H. Zhang , P. Swietach , B. Casadei , N. P. Smith, 2010 American Journal of Physiology, Voume 299 no. H1045-H1063

A mouse electrophysiology model fitted to mouse data at physiological temperatures and capable of pacing to physiological pacing rates.

Land, Niederer et al., Mouse Contraction Model 2012

An analysis of deformation-dependent electromechanical coupling in the mouse heart. Land S, Niederer SA, Aronsen JM, Espe EK, Zhang L, Louch WE, Sjaastad I, Sejersted OM, Smith NP. J Physiol. 2012 15;590(Pt 18):4553-69. Epub 2012 May 21. PubMed ID: 22615436

A model of contraction fitted to mouse data at physiological temperature and frequency, including length and velocity dependent tension generation.

Land and Niederer, Detailed Contraction Model 2015



A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges. Land S, Niederer SA. PLoS Computational Biology, 2015

A spatially detailed ODE model of contraction based on continuous flexible chain model of the thin filament. Includes explicit TnI kinetics and a biophysically detailed representation of RU-RU, RU-XB, and XB-XB cooperativity.

Land, Niederer et al., Human Contraction Model 2017



A model of cardiac contraction based on novel measurements of tension development in human cardiomyocytes. S Land, SJ Park-Holohan, NP Smith, CG Dos Remedios, JC Kentish, SA Niederer. JMCC, 2017

A model of human cardiac contraction intended for multi-scale modelling applications. Download includes relevant experimental data, and C++ code is available on request.